Synthesis, characterization, molecular docking and evaluation of anticancer activity of 2- pyrazoline derivatives
نویسندگان
چکیده
منابع مشابه
Novel Approach Synthesis, Molecular Docking and Cytotoxic Activity Evaluation of N-phenyl-2,2-dichloroacetamide Derivatives as Anticancer Agents
Dichloroacetate (DCA) as a small, cheap and available anticancer agent, is a pyruvate mimetic compound that stimulates the activity of pyruvate dehydrogenase (PDH) enzyme through inhibition of pyruvate dehydrogenase kinases (PDHK1-4). DCA turns on programed cell death (apoptosis) which suppressed in tumor cells and therefore inhibits tumor growth. DCA also interferes with the glucose uses of ca...
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A novel series of 1,3,5-trisubstituted-2-pyrazoline derivatives (PFC-1 to PFC-16) were synthesized in a three step reaction using conventional and microwave assisted green chemistry approach. The synthesized derivatives were characterized and their chemical structures were established by various physicochemical methods such as IR, Mass, 1H-NMR, 13C-NMR and elemental analysis. The synthesized co...
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15 صفحه اولSynthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents in HepG-2 Cell Line.
Cancer is a major public health concern worldwide. Adverse effects of cancer treatments still compromise patients' quality of life. To identify new potential anticancer agents, a series of novel pyrazoline derivatives were synthesized and evaluated for cytotoxic effects on HepG-2 (human liver hepatocellular carcinoma cell line) and primary hepatocytes. Compound structures were confirmed by ¹H-N...
متن کاملnovel approach synthesis, molecular docking and cytotoxic activity evaluation of n-phenyl-2,2-dichloroacetamide derivatives as anticancer agents
dichloroacetate (dca) as a small, cheap and available anticancer agent, is a pyruvate mimetic compound that stimulates the activity of pyruvate dehydrogenase (pdh) enzyme through inhibition of pyruvate dehydrogenase kinases (pdhk1-4). dca turns on programed cell death (apoptosis) which suppressed in tumor cells and therefore inhibits tumor growth. dca also interferes with the glucose uses of ca...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmacy and Pharmacology
سال: 2019
ISSN: 2455-2674
DOI: 10.31024/ajpp.2019.5.5.22